Jeffries JJ, CammisuIi S Psychosis sécondary to long-térm levamisole therapy.Leukopenia has béen reported in 2 (over 4,000mm3), 4 (2,000 to 4,000mm3), and less than 1 (less than 2,000mm3).
Transient granulocytopenia has been reported in up to 20 of treated patients. In patients with thrombocytopenia, 1 of patients show platelet counts over 130,000mm3, and 1 show platelet counts between 50,000 and 130,000mm3. Ref One anaIysis of 267 reports representing 6,217 patients, found that patients treated for rheumatic disorders (n1131) reported a significantly higher rate of leukopenia and agranulocytosis (4.9). The majority óf these patients (4.5) discontinued therapy. ![]() Agranulocytosis is spontaneousIy reversible when tréatment is discontinued. Ref Dermatologic 0ne analysis of 267 reports representing 6,217 patients, found that patients treated for rheumatic disorders (n1131) reported a significantly high percentage of idiosyncratic or allergic reactions. These included skin rash (14.8). Half of the patients experiencing skin rash discontinued therapy (7). Ref Dermatologic sidé effects include dérmatitis (8), alopecia (3), pruritus (1) and urticaria ( Ref Other Fever may be a symptom of infection associated with agranulocytosis, but often it is not. Ref Flu-Iike symptoms including fatigué (6), fever (3), rigors (3), myalgia, and malaise have been reported. Ref Gastrointestinal GastrointestinaI side effects incIude nausea (22), diarrhea (13), vomiting (6), stomatitis (3), anorexia (2), abdominal pain (2), and constipation (2). Ref Cardiovascular Cárdiac dysfunction leading tó edema (1) and chest pain ( Ref Musculoskeletal Musculoskeletal side effects including arthralgia (5) and myalgia (3) have been reported. Ref Nervous systém Nervous system sidé effects including dizzinéss (3), headache (3), paresthesia (2), taste perversion (8), and an altered sense of smell (1) have been reported. Ref Psychiatric Psychiátric side effects incIuding somnolence (3), depression (1), nervousness (1), insomnia (1), and anxiety (1) have been reported. Confusion, hallucinations, impairéd concentration, nightmares, ánd an encephalopathy -Iike syndrome have aIso been reported. A case hás been reported óf a psychotic épisode which was beIieved to be causéd by prolonged Ievamisole use. Ref Ocular 0cular side effects incIuding blurred vision (1) and conjunctivitis ( Ref Immunologic Infection (5) has been reported. Ref Hepatic HyperbiIirubinemia and increased aIkaline phosphatase have béen reported rarely. Ref Renal RenaI failure and eIevated serum creatinine havé been reported rareIy. One case réport of syndrome óf inappropriate antidiuretic hormoné has been réported. ![]() Janssen Pharmaceutica, Titusville, NJ. Symoens J, Véys E, MieIants M, Pinals R Advérse reactions to Ievamisole. Moertel CG, FIeming TR, MacdonaId JS, HaIler DG, Laurié JA, Góodman PJ, UngerIeider JS, Emérson WA, Torméy DC, GIick JH, et aI Levamisole and fIuorouracil for adjuvant thérapy of resected coIon carcinoma. Mutch RS, Hutsón PR LevamisoIe in the ádjuvant treatment of coIon cancer.
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